Nicotinic acid, its mechanism of action and pharmacological effects

Acute and Chronic Effects of Ferula persica on Blood Pressure of Hypertensive Rats and Its Possible Mechanism of Action

 Background: Ferula persica has been used in traditional medicine for treatment of high blood pressure. In this study acute and chronic effect of aqueous F. persica extract on BP of hypertensive rats and its possible mechanism of action have been investigated. Methods: Eighty two male Wistar rats were divided into 12 experimental groups. Hypertension was induced by Goldblatt method in ...

Study of Basil (Ocimum basilicum L) and its Mechanism of Action on Type 2 Diabetes

Introduction: Diabetes mellitus is a chronic metabolic disease with life threatening complications such as diabetic retinopathy, renal failure and cardiovascular disease. Metformin, Glibenclamide, Acarbose, Empagliflozin, Sitagliptin and Repaglinide are the most common drugs for reducing the blood glucose. The blood glucose-lowering drugs have side effects such as severe hypoglycemia, liver cel...

Hepatoprotective Activity of Camellia Sinensis and Its Possible Mechanism of Action

The present study appraised the hepatoprotective activity of aqueous extract of Camellia sinensis leaves and its possible mechanism of action against carbon-tetrachloride-induced liver damage. Liver damage was induced by   intraperitoneal administration of equal mixture of carbon tetrachloride   and olive oil (50 % v/v, 0.5 ml/kg ) in male Wistar rats (150-220g) once daily for...

Musk: Its Pharmacological Action and Therapeutic Uses

Antinociceptive and pharmacological effects of metanicotine, a selective nicotinic agonist.

Metanicotine [N-methyl-4-(3-pyridinyl)-3-butene-1-amine], a novel neuronal nicotinic agonist, was found to bind with high affinity (K(i) = 24 nM) to rat brain [(3)H]nicotine binding sites and it generalized to nicotine in a dose-dependent manner in the drug discrimination procedure. Metanicotine produced significant antinociceptive effects in mice and rats subjected to either acute thermal (tai...